MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Curr Opin Cell Biol. 2012 Apr;24(2):166-72. doi: 10.1016/j.ceb.2011.12.010. Epub 2012 Jan 16.
The need to coordinate patterning and growth has been appreciated for many years. The logic that enables seamless integration of the relevant inputs is beginning to be elucidated, particularly in wing imaginal discs of Drosophila. In this tissue, multiple regulatory layers involving the two morphogens Wingless and Dpp, the wing-specific determinant, Vestigial, and the Hippo pathway, converge to regulate growth. Intricate cross-regulation between these components may explain why, at the local level, there is no direct correlation between growth and the graded signalling activity of Wingless and Dpp, despite the requirement of these two pathways for growth.
多年来，人们已经认识到协调形态发生和生长的必要性。相关输入的无缝集成逻辑开始被阐明，特别是在果蝇的翅膀 imaginal 盘中。在这个组织中，涉及两种形态发生素 Wingless 和 Dpp、翅膀特异性决定因子 Vestigial 和 Hippo 途径的多个调节层汇聚在一起调节生长。这些成分之间复杂的交叉调节可能解释了为什么尽管这两条途径都需要生长，但在局部水平上，生长与 Wingless 和 Dpp 的梯度信号活性之间没有直接的相关性。
