School of Population Health, The University of Queensland, Brisbane, Australia.
Pediatr Res. 2012 Feb;71(2):215-9. doi: 10.1038/pr.2011.25. Epub 2011 Dec 21.
This study aimed to examine the association between cannabis use before and during pregnancy and birth outcomes.
Overall, 26.3% of women reported previous use of cannabis and 2.6% reported current use. Multivariate analysis, controlling for potential confounders, including tobacco smoking, alcohol consumption, and use of other illicit drugs, showed that cannabis use in pregnancy was associated with low birth weight (odds ratio (OR) = 1.7; 95% confidence interval (CI): 1.3-2.2), preterm labor (OR = 1.5; 95% CI: 1.1-1.9), small for gestational age (OR = 2.2; 95% CI: 1.8-2.7), and admission to the neonatal intensive care unit (OR = 2.0; 95% CI: 1.7-2.4).
The results of this study show that the use of cannabis in pregnancy is associated with increased risk of adverse birth outcomes. Prevention programs that address cannabis use during pregnancy are needed.
Data were from women birthing at the Mater Mothers' Hospital in Brisbane, Australia, over a 7-y period (2000-2006). Women were interviewed in the initial antenatal visit about their use of cannabis and other substances. Records for 24,874 women who provided information about cannabis use, and for whom birth outcomes data were available, were included in the analysis.
本研究旨在探讨妊娠前后使用大麻与生育结局之间的关联。
总体而言，26.3%的女性报告在妊娠前使用过大麻，2.6%的女性报告在妊娠期间使用过大麻。多变量分析，控制了包括吸烟、饮酒和使用其他非法药物在内的潜在混杂因素，结果显示，妊娠期间使用大麻与低出生体重（比值比（OR）=1.7；95%置信区间（CI）：1.3-2.2）、早产（OR=1.5；95%CI：1.1-1.9）、小于胎龄儿（OR=2.2；95%CI：1.8-2.7）和新生儿重症监护病房（NICU）入住（OR=2.0；95%CI：1.7-2.4）有关。
本研究结果表明，妊娠期间使用大麻与不良生育结局风险增加有关。需要制定针对妊娠期间大麻使用的预防计划。
数据来自澳大利亚布里斯班 Mater Mothers' 医院在 7 年期间（2000-2006 年）分娩的女性。在最初的产前检查中，女性被询问关于她们使用大麻和其他物质的情况。在分析中纳入了 24874 名提供了大麻使用信息且生育结局数据可用的女性的记录。
