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肝脏特异性 microRNA-122：生物发生与功能。

Liver-specific microRNA-122: Biogenesis and function.

机构信息

Centre for Biomolecular Sciences; University of Nottingham; University Park; Nottingham, UK.

出版信息

RNA Biol. 2012 Feb;9(2):137-42. doi: 10.4161/rna.18827. Epub 2012 Feb 1.

DOI:10.4161/rna.18827
PMID:22258222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346312/
Abstract

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.

摘要

miR-122（microRNA-122）是组织特异性 miRNA 的首例之一。它在肝脏中高度表达，占总 miRNA 池的 70%。miR-122 的表达是脊椎动物谱系所特有的，成熟 miRNA 的序列完全保守。由于 miR-122 与胆固醇代谢和肝细胞癌有关，并且在促进丙型肝炎病毒（HCV）复制方面发挥着重要作用，因此它是研究的重点。本综述将讨论 miR-122 的生物发生和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5886/3346312/89cd2f23c2fe/rna-9-137-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5886/3346312/89cd2f23c2fe/rna-9-137-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5886/3346312/89cd2f23c2fe/rna-9-137-g1.jpg

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CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation.CPEB 和两种 poly(A) 聚合酶控制 miR-122 的稳定性和 p53 mRNA 的翻译。
Nature. 2011 May 5;473(7345):105-8. doi: 10.1038/nature09908. Epub 2011 Apr 10.
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