在波兰荷斯坦弗里森牛的 PRNP 基因启动子和内含子 1 区域的多态性位点，等位基因和单倍型的异常分离。
Abnormal segregation of alleles and haplotypes at the polymorphic site of the PRNP gene within promoter and intron 1 regions in Polish Holstein-Friesian cattle.
机构信息
Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, M. Oczapowskiego 5, 10-957 Olsztyn, Poland.
出版信息
Biochem Genet. 2012 Aug;50(7-8):520-8. doi: 10.1007/s10528-012-9496-2. Epub 2012 Jan 19.
Allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP gene was analyzed in Polish Holstein-Friesian cattle. More 23del/del homozygotes and fewer 23ins/ins homozygotes than expected were observed in the offspring of ♂ 23ins/del × ♀ 23ins/del parents. In the offspring of ♂ 23ins/del × ♀ 23del/del parents and ♂ 23del/del × ♀ 23ins/del parents, a trend toward more 23del/del animals and fewer 23ins/del animals than expected was noted. At the 12indel polymorphic site, the only trend found was one toward fewer 12ins/ins genotypes and more 12ins/del and 12del/del genotypes than expected in the offspring of ♂ 12ins/del × ♀ 12ins/del parents. An analysis of haplotype segregation revealed more 23del-12del/23del-12del diplotypes and fewer 23ins-12ins/23ins-12ins diplotypes at the significance threshold than expected in the offspring of ♂ 23ins-12ins/23del-12del × ♀ 23ins-12ins/23del-12del parents.
在波兰荷斯坦-弗里森牛中分析了 PRNP 基因启动子（23indel）和内含子 1（12indel）区域内多态性位点的等位基因和单倍型分离。在♂23ins/del×♀23ins/del 父母的后代中观察到比预期更多的 23del/del 纯合子和更少的 23ins/ins 纯合子。在♂23ins/del×♀23del/del 父母和♂23del/del×♀23ins/del 父母的后代中，注意到有更多 23del/del 动物和更少 23ins/del 动物的趋势比预期的要多。在 12indel 多态性位点，仅发现一个趋势，即在♂12ins/del×♀12ins/del 父母的后代中，12ins/ins 基因型比预期的少，12ins/del 和 12del/del 基因型比预期的多。单倍型分离分析显示，在♂23ins-12ins/23del-12del×♀23ins-12ins/23del-12del 父母的后代中，23del-12del/23del-12del 双体比预期的多，而 23ins-12ins/23ins-12ins 双体比预期的少。
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