Flynn Colleen, Bakris George L
Cardiorenal Med. 2011;1(2):96-101. doi: 10.1159/000327023. Epub 2011 Apr 15.
More than two thirds of the US population are considered overweight or obese. Adipocytes are now appreciated as important endocrine organs, secreting various factors with hormonal effects. Several different adipokines have been identified, including adiponectin, which is associated with improved insulin sensitivity, a better lipoprotein profile, and lower rates of vascular inflammation and cardiovascular disease. Several studies have identified the renin-angiotensin-aldosterone system as important in the regulation of adiponectin. These studies lay the fundamental groundwork for developing targeted therapies with potential to reduce the burden of obesity-associated diseases, such as the cardiorenal metabolic syndrome.
超过三分之二的美国人口被认为超重或肥胖。脂肪细胞现在被视为重要的内分泌器官，分泌具有激素作用的各种因子。已经鉴定出几种不同的脂肪因子，包括脂联素，它与改善胰岛素敏感性、更好的脂蛋白谱以及降低血管炎症和心血管疾病的发生率有关。几项研究已确定肾素 - 血管紧张素 - 醛固酮系统在脂联素的调节中很重要。这些研究为开发有潜力减轻肥胖相关疾病（如心肾代谢综合征）负担的靶向疗法奠定了基础。
