Department of Endocrinology and Internal Medicine, Medical University, Gdańsk, Poland.
Endokrynol Pol. 2010 Jan-Feb;61(1):36-41.
Obesity is a disease that brings several complications and increases the risk of other diseases like metabolic syndrome, diabetes mellitus type 2, or coronary heart disease. Disturbances in secretion of adipokines caused by obesity have an influence on the development of metabolic complications. The aim of this study was an investigation of adipokines profile in overweight or obese people with metabolic syndrome in comparison to overweight/obese patients without metabolic syndrome.
The studied groups consisted of 38 obese or overweight patients without metabolic syndrome (nonMS) and 17 with recognized metabolic syndrome (MS), according to International Diabetes Federation (IDF) criteria. All individuals underwent anthropometrical and blood-pressure examination as well as biochemical analyses such as: serum concentrations of glucose, insulin, adiponectin, resistin, leptin, TNF-alpha, IL-6, hs-CRP, total cholesterol, HDL, and triglycerides.
A significantly lower concentration of adiponectin, and a higher concentration of IL-6, was observed in patients with metabolic syndrome (MS) in comparison to nonMS. Moreover, higher concentrations of hs-CRP and TNF-alpha were observed in patients with metabolic syndrome.
A decreased concentration of adiponectin in obese people is an early predictor of metabolic syndrome. A low adiponectin level could be a marker of high risk of cardiovascular disease in obese patients. (Pol J Endocrinol 2010; 61 (1): 36-41).
肥胖是一种会带来多种并发症的疾病，增加了代谢综合征、2 型糖尿病或冠心病等其他疾病的风险。肥胖引起的脂联素分泌紊乱对代谢并发症的发展有影响。本研究旨在调查超重或肥胖合并代谢综合征患者与无代谢综合征的超重/肥胖患者的脂联素谱。
研究对象包括 38 名无代谢综合征的超重或肥胖患者（非 MS）和 17 名符合国际糖尿病联合会（IDF）标准的代谢综合征患者。所有患者均进行了体格检查和血压检查以及生化分析，如血清葡萄糖、胰岛素、脂联素、抵抗素、瘦素、TNF-α、IL-6、hs-CRP、总胆固醇、HDL 和甘油三酯浓度。
与非 MS 患者相比，代谢综合征（MS）患者的脂联素浓度显著降低，IL-6 浓度显著升高。此外，代谢综合征患者的 hs-CRP 和 TNF-α浓度更高。
肥胖人群中脂联素浓度降低是代谢综合征的早期预测指标。脂联素水平低可能是肥胖患者心血管疾病高风险的标志物。（波兰内分泌学会杂志 2010；61（1）：36-41）。
