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可生物降解的聚二氧六环酮支架在治疗术后结直肠狭窄和瘘中的应用。

Usefulness of biodegradable polydioxanone stents in the treatment of postsurgical colorectal strictures and fistulas.

机构信息

Department of Gastroenterology, Hospital General La Mancha-Centro, Avenida de la Constitución 3, Alcázar de San Juan, Spain.

出版信息

Endoscopy. 2012 Mar;44(3):297-300. doi: 10.1055/s-0031-1291482. Epub 2012 Jan 19.

DOI:10.1055/s-0031-1291482
PMID:22261748
Abstract

Benign colonic strictures and fistulas are a growing problem presenting most commonly after bowel resection. Standard treatment is with endoscopic bougies or, more usually, balloon dilation. When these approaches are not successful, other solutions are available and different endoscopic and surgical approaches have been used to treat fistulas. We present an additional option--biodegradable stents--for the treatment of colonic strictures and fistulas that have proven refractory to other endoscopic interventions. We analyzed the results from 10 patients with either a postsurgical colorectal stricture (n =7) or rectocutaneous fistula (n =3) treated with the biodegradable SX-ELLA esophageal stent (covered or uncovered). Stents were successfully placed in nine patients, although early migration subsequently occurred in one. Placement was impossible in one patient due to deformity of the area and the fact that the stricture was approximately 30cm from the anus. The fistulas were successfully closed in all patients, although symptoms reappeared in one patient. In the six patients who received stents for strictures, symptoms resolved in five; in the remaining patient, the stent migrated shortly after the endoscopy. Treatment of colonic strictures and rectocutaneous fistulas with biodegradable stents is an effective alternative in the short-to-medium term. The stent does not have to be removed and is subject to very few complications. The drawbacks of this approach are the need to repeat the procedure in some patients and the lack of published series on efficacy.

摘要

良性结肠狭窄和瘘管是一个日益严重的问题,最常见于肠切除术后。标准治疗方法是使用内镜探条或更常见的球囊扩张。当这些方法不成功时,还有其他解决方案,不同的内镜和手术方法已被用于治疗瘘管。我们提出了一种额外的选择——可生物降解支架——用于治疗对其他内镜干预措施有抗性的结肠狭窄和瘘管。我们分析了 10 名患者的结果,这些患者要么患有术后结直肠狭窄(n=7),要么患有直肠皮瘘(n=3),他们接受了可生物降解的 SX-ELLA 食管支架(覆盖或未覆盖)治疗。虽然有一个支架在早期发生了迁移,但在九名患者中成功放置了支架。在一名患者中,由于该区域的畸形以及狭窄距离肛门约 30 厘米,放置支架是不可能的。所有患者的瘘管都成功闭合,尽管有一位患者的症状再次出现。在接受支架治疗狭窄的六名患者中,五名患者的症状得到缓解;其余患者的支架在内镜检查后不久就迁移了。在短期至中期内,可生物降解支架治疗结肠狭窄和直肠皮瘘是一种有效的替代方法。支架不需要取出,并且很少出现并发症。这种方法的缺点是需要在一些患者中重复该操作,并且缺乏关于疗效的已发表系列。

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