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[不同营养条件下,带Guérin氏癌的Wistar大鼠器官和组织总脂质中14C-葡萄糖标记掺入的特征]

[The characteristics of the incorporation of the 14C-glucose label into the total lipids of the organs and tissues of Wistar rats with Guérin's carcinoma under differing nutritional conditions].

作者信息

Tagi-zade S B, Orudzhli R N

出版信息

Eksp Onkol. 1990;12(5):67-70.

PMID:2226264
Abstract

Peculiarities of 14C-glucose label incorporation into total lipids (TL) of organs, tissues, blood serum and tumors in rats with the Guérin carcinoma under different nutrition conditions have been studied. It is determined that after recycling 14C-glucose is used in TL synthesis of organs, tissues, tumor which may be again involved in the process of metabolism, that evidences for the function of the synthesis mechanism and mobilization of TL. With an increase of tumor mass the specific activity of label in TL of organs and tissues decreases. In contrast to organs and tissues, the tumor involves 14C-glucose into synthesis of own TL independent of nutrition conditions, their level does not decrease in starvation.

摘要

研究了不同营养条件下,14C-葡萄糖标记物掺入患有格林氏癌大鼠的器官、组织、血清和肿瘤的总脂质(TL)中的特点。结果表明,再循环后,14C-葡萄糖用于器官、组织和肿瘤的TL合成,这些TL可能再次参与代谢过程,这证明了TL合成机制和动员的功能。随着肿瘤质量的增加,器官和组织TL中标记物的比活性降低。与器官和组织不同,肿瘤将14C-葡萄糖掺入自身TL的合成中,与营养条件无关,在饥饿状态下其水平不会降低。

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