Medovar B Ia
Ukr Biokhim Zh. 1976 Sep-Oct;48(5):572-6.
Peculiarities of 14C incorporation into proteins and lipids of the liver, kidneys, heart and muscles tissues as well as blood serum and protein-free filtrates of tissues were studied in young and old rats in different periods after glycin-2-14C administration. It is shown that incorporation of 14C into the tissue of young rats as well as its evacuation from the organism is more rapid. At the same time a change in dynamics of the precursors content in individual organs of animals of both age groups is of indirected character. A conclusion is drawn that acceleration of the radioactive label evacuation due to a more rapid exchange--ability of proteins in the young animals tissues might be one of the reasons of discrepancy between a higher level of radioactivity in the tissues of old rats and a total decrease in the intensity of metabolism during ontogenesis.
在给甘氨酸-2-¹⁴C后不同时期，研究了¹⁴C掺入年轻和老年大鼠肝脏、肾脏、心脏和肌肉组织以及血清和组织无蛋白滤液中蛋白质和脂质的特点。结果表明，¹⁴C掺入年轻大鼠组织以及从机体排出的速度更快。同时，两个年龄组动物各个器官中前体含量动态变化具有非定向性。得出结论，由于年轻动物组织中蛋白质交换能力更快，放射性标记物排出加速，这可能是老年大鼠组织中放射性水平较高与个体发育过程中代谢强度总体下降之间差异的原因之一。
