Lawrence Johnathan E, Cook Nicholas J, Rovin Richard A, Winn Robert J
Biology Department, Northern Michigan University (NMU), Marquette, MI 49855, USA.
Neurol Res Int. 2012;2012:870807. doi: 10.1155/2012/870807. Epub 2012 Jan 4.
The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. In these models, positive mental stimulation through environmental enrichment decreased leptin secretion and improved tumor outcome. This review explores the link between leptin and glioblastoma.
瘦素这种激素具有多种功能。瘦素最初因其在饱腹感和体重减轻方面的作用而为人所知，最近研究表明它在多种癌症中会促进肿瘤生长。在胶质瘤中，肿瘤分级与瘦素及其受体的肿瘤表达之间存在相关性。这表明肿瘤微环境中的自分泌信号可能促进高级别胶质瘤的生长。瘦素通过刺激对肿瘤生长和复发也有利的细胞途径来实现这一点：抗凋亡、增殖、血管生成和迁移。相反，瘦素表达缺失会减弱肿瘤生长。在结肠癌和黑色素瘤的动物模型中，瘦素表达和分泌的下降导致肿瘤生长减缓。在这些模型中，通过环境富集进行积极的精神刺激可减少瘦素分泌并改善肿瘤预后。本综述探讨了瘦素与胶质母细胞瘤之间的联系。
