State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.
J Agric Food Chem. 2012 Feb 15;60(6):1413-8. doi: 10.1021/jf204748a. Epub 2012 Feb 3.
The aim of the present study was to investigate whether oxidative stress and immune dysfunction could be attenuated by Ganoderma atrum polysaccharide (PSG-1) in d-galactose (d-gal)-induced aging mice, and provide evidence for its effects. The results showed that PSG-1 significantly decreased lipid peroxidation in liver, brain, and spleen, but concomitantly increased the activities of superoxide dismutase, catalase, and glutathione peroxidase compared with the d-gal group. Elevation of glutathione contents and attenuation of glutathione disulfide contents were also found in PSG-1-treated animals. Furthermore, the results showed that PSG-1 treatment increased basal lymphocyte proliferation as well as T cell and B cell proliferation and enhanced interleukin-2 production. Taken together, the results suggested that PSG-1 had potential as a novel agent to promote health and improve aging-associated pathologies, at least in part, via modification of the redox system and improvement of immune function.
本研究旨在探讨灵芝多糖（PSG-1）是否能减轻半乳糖（d-gal）诱导的衰老小鼠的氧化应激和免疫功能障碍，并为其作用提供证据。结果表明，与 d-gal 组相比，PSG-1 能显著降低肝、脑和脾中的脂质过氧化，但同时增加超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。在 PSG-1 处理的动物中还发现了谷胱甘肽含量的升高和谷胱甘肽二硫化物含量的降低。此外，结果表明 PSG-1 治疗可增加基础淋巴细胞增殖以及 T 细胞和 B 细胞增殖，并增强白细胞介素-2 的产生。综上所述，这些结果表明 PSG-1 具有通过调节氧化还原系统和改善免疫功能来促进健康和改善与衰老相关的病理的潜力。
