Alarfaj Nawal A, Ammar Reda A, El-Tohamy Maha F
Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia.
Chem Cent J. 2012 Jan 21;6:6. doi: 10.1186/1752-153X-6-6.
A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.
采用丝网印刷技术开发了一种用于测定盐酸度洛西汀（DL）的丝网印刷一次性电极系统。基于改性剂和增塑剂的影响，对自制印刷进行了表征和优化。所制备的包含工作电极和参比电极的双电极电位测定条用作盐酸度洛西汀传感器。所提出的传感器在1.0×10⁻⁶ - 1.0×10⁻² mol L⁻¹的浓度范围内工作良好，检测限达到5.0×10⁻⁷ mol L⁻¹，保质期为6个月。该方法准确、精密且经济。所提出的方法已成功应用于该药物纯品及其剂型的分析。在该方法中，不受任何常见药物添加剂和稀释剂的干扰。通过回收率研究对分析结果进行了统计学验证。
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