Microanalysis Laboratory, National Research Centre, Dokki, Giza, Egypt.
Talanta. 2010 Apr 15;81(1-2):510-5. doi: 10.1016/j.talanta.2009.12.033. Epub 2009 Dec 28.
The construction and performance characteristics of dextromethorphan (DXM) carbon paste (CPEs) and polyvinyl chloride (PVC) electrodes are described. Different modes for electrode modification, including incorporation of ion pairs (IPs), ion pairing agent or soaking the plain electrode in IPs suspension, have been used. Matrices compositions were optimized referring to the effect of modifier and plasticizer. The fabricated electrodes work satisfactorily in the concentration range from 10(-5) to 10(-2) mol L(-1) with fast response time (1.6s) and long operational lifetime (2 months). The developed electrodes have been successfully applied for the potentiometric determination of DXM in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. Under FIA conditions, the proposed electrodes allow the analysis of 90 samples h(-1) and offer the advantage of simplicity, accuracy and automation feasibility. The solubility products of various DXM-IPs were determined conductometrically.
描述了右美沙芬（DXM）碳糊（CPEs）和聚氯乙烯（PVC）电极的构建和性能特点。使用了不同的电极修饰模式，包括离子对（IPs）的掺入、离子对试剂或将普通电极浸泡在 IPs 悬浮液中。根据修饰剂和增塑剂的影响优化了基质组成。制备的电极在 10(-5) 到 10(-2) mol L(-1) 的浓度范围内工作良好，响应时间快（1.6s），使用寿命长（2 个月）。在批处理和流动注射分析（FIA）条件下，开发的电极已成功用于药物制剂中 DXM 的电位测定。在 FIA 条件下，建议的电极允许分析 90 个样品 h(-1)，并具有简单、准确和自动化可行性的优点。通过电导率法测定了各种 DXM-IP 的溶度积。
