当一个细胞就足够了。
When one cell is enough.
机构信息
Regenerative Medicine Institute, National University of Ireland, University Road, Galway, Ireland.
出版信息
Stem Cell Res Ther. 2012 Jan 13;3(1):1. doi: 10.1186/scrt92.
Abstract
For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secondary hosts. That clinical bone marrow transplantation is a successful treatment strategy is indirect evidence that such a cell exists in humans. To date, similar criteria have not been applied to human HSCs. However, using a humanized mouse model of xenotransplantation, a recent paper shows that single human cells can fully reconstitute the lymphomyeloid system of primary recipient animals and, in some cases, that of secondary hosts.
摘要
多年来，造血干细胞（HSC）在小鼠中已得到很好的描述，它是一种能够单独重建原始受者动物以及次级宿主整个造血系统的细胞。临床骨髓移植是一种成功的治疗策略，这间接证明了这种细胞在人类中存在。迄今为止，尚未将类似的标准应用于人类 HSC。然而，利用人源化异种移植小鼠模型，最近的一篇论文表明，单个人类细胞可以完全重建原始受者动物的淋巴骨髓系统，在某些情况下，还可以重建次级宿主的系统。
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本文引用的文献
1
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.分离能够长期多谱系植入的单个人类造血干细胞。
Science. 2011 Jul 8;333(6039):218-21. doi: 10.1126/science.1201219.
2
Models of haematopoiesis: seeing the wood for the trees.造血模型：见树木更见森林。
Nat Rev Immunol. 2009 Apr;9(4):293-300. doi: 10.1038/nri2525.
3
Humanized mice in translational biomedical research.转化生物医学研究中的人源化小鼠。
Nat Rev Immunol. 2007 Feb;7(2):118-30. doi: 10.1038/nri2017.
4
Transient nature of early haematopoietic spleen colonies.早期造血脾集落的短暂性质。
Nature. 1982 Feb 11;295(5849):527-9. doi: 10.1038/295527a0.
5
Purification and characterization of mouse hematopoietic stem cells.小鼠造血干细胞的纯化与鉴定
Science. 1988 Jul 1;241(4861):58-62. doi: 10.1126/science.2898810.
6
Clonal fluctuation within the haematopoietic system of mice reconstituted with retrovirus-infected stem cells.用逆转录病毒感染的干细胞重建的小鼠造血系统内的克隆波动。
EMBO J. 1987 Dec 20;6(13):3955-60. doi: 10.1002/j.1460-2075.1987.tb02737.x.
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