Regenerative Medicine Institute, National University of Ireland, University Road, Galway, Ireland.
Stem Cell Res Ther. 2012 Jan 13;3(1):1. doi: 10.1186/scrt92.
For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secondary hosts. That clinical bone marrow transplantation is a successful treatment strategy is indirect evidence that such a cell exists in humans. To date, similar criteria have not been applied to human HSCs. However, using a humanized mouse model of xenotransplantation, a recent paper shows that single human cells can fully reconstitute the lymphomyeloid system of primary recipient animals and, in some cases, that of secondary hosts.
多年来，造血干细胞（HSC）在小鼠中已得到很好的描述，它是一种能够单独重建原始受者动物以及次级宿主整个造血系统的细胞。临床骨髓移植是一种成功的治疗策略，这间接证明了这种细胞在人类中存在。迄今为止，尚未将类似的标准应用于人类 HSC。然而，利用人源化异种移植小鼠模型，最近的一篇论文表明，单个人类细胞可以完全重建原始受者动物的淋巴骨髓系统，在某些情况下，还可以重建次级宿主的系统。
