布鲁氏菌“搭乘”自噬。

Brucella "hitches a ride" with autophagy.

机构信息

Cell Biology Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

出版信息

Cell Host Microbe. 2012 Jan 19;11(1):2-4. doi: 10.1016/j.chom.2012.01.003.

DOI:10.1016/j.chom.2012.01.003

Abstract

Autophagy involves lysosomal-mediated degradation of cellular components and contributes to host immunity. Some pathogens avoid autophagy-mediated killing, while others exploit it to acquire host cell nutrients. Starr et al. reveal that the intracellular bacterial pathogen Brucella abortus can "hitch a ride" with autophagy, subverting autophagy machinery to spread from cell to cell (Starr et al., 2012).

摘要

自噬涉及溶酶体介导的细胞成分降解，并有助于宿主免疫。一些病原体逃避自噬介导的杀伤，而另一些则利用它来获取宿主细胞营养。Starr 等人揭示了胞内细菌病原体布鲁氏菌可以“搭便车”进行自噬，颠覆自噬机制从而在细胞间传播（Starr 等人，2012 年）。