Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Semin Neurol. 2011 Nov;31(5):470-83. doi: 10.1055/s-0031-1299786. Epub 2012 Jan 21.
Over the past 20 years, nucleotide repeat expansion disorders have informed our broader understanding of neurodevelopmental and neurodegenerative disease. This is especially true with regard to the contributions of epigenetic mechanisms to neurologic disease pathogenesis. In this review, the authors describe a few of the myriad ways in which epigenetic processes underlie aspects of repeat expansion disorder pathophysiology and discuss how therapies targeted at epigenetic modulation hold promise for many of these disorders.
在过去的 20 年中，核苷酸重复扩展疾病使我们对神经发育和神经退行性疾病有了更广泛的认识。这在表观遗传机制对神经疾病发病机制的贡献方面尤其如此。在这篇综述中，作者描述了表观遗传过程在重复扩展疾病病理生理学方面的无数种方式，并讨论了针对表观遗传调节的治疗方法如何为许多这些疾病带来希望。
