Department of Chemistry/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea.
Chem Commun (Camb). 2012 Feb 25;48(17):2331-3. doi: 10.1039/c2cc17496k. Epub 2012 Jan 23.
We developed a novel fluorescent bioprobe (SF44) that can specifically visualize the cellular lipid droplets in in vitro and in vivo systems and illustrated the mechanistic rationale of its fluorogenic property. Its application to image-based high throughput screening led us to the identification of a new small-molecule modulator of lipid droplet formation.
我们开发了一种新型荧光生物探针（SF44），可特异性地在体外和体内系统中可视化细胞脂滴，并阐明了其荧光性质的机制原理。将其应用于基于成像的高通量筛选，使我们能够鉴定出一种新的脂滴形成小分子调节剂。
