Tregubov A L, Kolla V E
Farmakol Toksikol. 1990 Jul-Aug;53(4):19-21.
In the experiments on white mice there was studied the anticonvulsant activity by the test of the maximal electric shock and acute toxicity of anticonvulsants and antidepressants at separate and combined administration. The combined use of anticonvulsants and antidepressants showed the increase of the anticonvulsant activity of phenobarbital with amitriptyline, levomepromazine and lithium oxybutyrate; diphenine and carbamazepine with amitriptyline as well as hexamidine with all antidepressants. The combination of phenobarbital with amitriptyline, levomepromazine and lithium oxybutyrate, diphenine with amitriptyline, hexamidine with amitriptyline and imizine proved to be the safest.
在对白鼠的实验中，通过最大电击试验研究了抗惊厥药和抗抑郁药单独及联合给药时的抗惊厥活性和急性毒性。抗惊厥药和抗抑郁药联合使用时，苯巴比妥与阿米替林、左美丙嗪和羟丁酸锂联合使用，抗惊厥活性增强；双苯乙胺和卡马西平与阿米替林联合使用，以及己脒与所有抗抑郁药联合使用时，抗惊厥活性也增强。苯巴比妥与阿米替林、左美丙嗪和羟丁酸锂联合使用，双苯乙胺与阿米替林联合使用，己脒与阿米替林和咪嗪联合使用被证明是最安全的。
