关于乳腺癌中ESR1基因扩增的证据。 - Suppr

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On the evidence for ESR1 amplification in breast cancer.

作者信息

Holst Frederik, Moelans Cathy B, Filipits Martin, Singer Christian F, Simon Ronald, van Diest Paul J

出版信息

Nat Rev Cancer. 2012 Jan 24;12(2):149. doi: 10.1038/nrc3093-c3.

DOI:10.1038/nrc3093-c3

PMID:22270954

Abstract

摘要

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Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial.

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Genetic heterogeneity in HER2 testing may influence therapy eligibility.

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The different roles of ER subtypes in cancer biology and therapy.

Nat Rev Cancer. 2011 Jul 22;11(8):597-608. doi: 10.1038/nrc3093.

ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1.

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ESR1 amplification is rare in breast cancer and is associated with high grade and high proliferation: a multiplex ligation-dependent probe amplification study.

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Amplification of ESR1 may predict resistance to adjuvant tamoxifen in postmenopausal patients with hormone receptor positive breast cancer.

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