Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC, Canada.
J Biophotonics. 2012 Apr;5(4):313-26. doi: 10.1002/jbio.201100093. Epub 2012 Jan 23.
The tools and techniques developed for analytical cytology have become invaluable in expanding the development of cancer screening programs and biomarker discovery for personalized medicine. Detecting cellular, molecular, and functional changes of diseased tissue as defined by quantitative analytical methodologies has enhanced the field of medical diagnostics and prognostics. The focus of this review is to outline applications and recent technical advances in flow cytometry, laser scanning cytometry, image cytometry, and quantitative image analysis, as they pertain to clinical, research, and drug discovery applications.
用于分析细胞学的工具和技术在扩展癌症筛查计划和个性化医学的生物标志物发现方面变得非常有价值。通过定量分析方法检测疾病组织的细胞、分子和功能变化，增强了医学诊断和预后领域。本文综述的重点是概述流式细胞术、激光扫描细胞术、图像细胞术和定量图像分析在临床、研究和药物发现应用中的应用和最新技术进展。
