利用微秒级磁刺激对嵌入生物组织中的磁性氧化铁纳米颗粒进行磁声成像。
Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation.
作者信息
Hu Gang, He Bin
机构信息
Department of Biomedical Engineering, University of Minnesota, Minnesota 55455, USA.
出版信息
Appl Phys Lett. 2012 Jan 2;100(1):13704-137043. doi: 10.1063/1.3675457. Epub 2012 Jan 6.
Abstract
We present an experimental study on magnetoacoustic imaging of superparamagnetic iron oxide (SPIO) nanoparticles embedded in biological tissues. In experiments, a large-current-carrying coil is used to deliver microsecond pulsed magnetic stimulation to samples. The ultrasound signals induced by magnetic forces on SPIO nanoparticles are measured by a rotating transducer. The distribution of nanoparticles is reconstructed by a back-projection imaging algorithm. The results demonstrated the feasibility to obtain cross-sectional image of magnetic nanoparticle targets with faithful dimensional and positional information, which suggests a promising tool for tomographic reconstruction of magnetic nanoparticle-labeled diseased tissues (e.g., cancerous tumor) in molecular or clinic imaging.
摘要
我们展示了一项关于嵌入生物组织中的超顺磁性氧化铁（SPIO）纳米颗粒的磁声成像实验研究。在实验中，使用大电流线圈向样本施加微秒级脉冲磁刺激。通过旋转换能器测量SPIO纳米颗粒上磁力诱导产生的超声信号。利用反投影成像算法重建纳米颗粒的分布。结果证明了获取具有准确尺寸和位置信息的磁性纳米颗粒目标横截面图像的可行性，这表明在分子或临床成像中，它是用于磁性纳米颗粒标记的病变组织（如癌性肿瘤）断层重建的一种有前景的工具。
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