Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
J Pharm Sci. 2010 Nov;99(11):4658-68. doi: 10.1002/jps.22168.
The magnetic induced deposition of polydispersed aerosols composed of agglomerated superparamagnetic particles was measured with an in vitro model system and in the mouse trachea and deep lung for the purpose of investigating the potential of site specific respiratory drug delivery. Oleic acid coated superparamagnetic particles were prepared and characterized by TEM, induced magnetic moment, and iron content. The particles were dispersed in cyclohexane, aerosolized with an ultrasonic atomizer and dried by sequential reflux and charcoal columns. The fraction of iron deposited on glass tubes increased with particle size and decreasing flow rate. High deposition occurred with a small diameter tube, but the deposition fraction was largely independent of tube size at larger diameters. Results from computational fluid dynamics qualitatively agreed with the experimental results. Enhanced deposition was observed in the mouse lung but not in the trachea consistent with the analysis of the aerodynamic time allowed for deposition and required magnetic deposition time.
为了研究靶向呼吸药物传递的可能性，我们使用体外模型系统和小鼠气管及深肺进行了由团聚超顺磁颗粒组成的多分散气溶胶的磁诱导沉积测量。通过 TEM、感应磁矩和铁含量对油酸包覆的超顺磁颗粒进行了制备和表征。将这些颗粒分散在环己烷中，使用超声雾化器进行雾化，并通过连续回流和木炭柱进行干燥。沉积在玻璃管上的铁的分数随粒径的增大和流速的降低而增加。在小直径管中会发生高沉积，但在较大直径管中，沉积分数在很大程度上与管的尺寸无关。计算流体动力学的结果与实验结果定性一致。在小鼠肺中观察到增强的沉积，但在气管中没有观察到，这与沉积允许的空气动力学时间和所需的磁沉积时间的分析一致。
