Tada Yukie, Yano Norio, Takahashi Hiroshi, Yuzawa Katsuhiro, Ando Hiroshi, Kubo Yoshikazu, Nagasawa Akemichi, Chin Keigi, Kawamata Yasuko, Sakai Ryosei, Ohashi Norio, Ogata Akio, Nakae Dai
J Toxicol Pathol. 2010 Mar;23(1):39-47. doi: 10.1293/tox.23.39. Epub 2010 Apr 5.
A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, water intake or urinalysis data. In several of the hematology, serum biochemistry and organ weight parameters, significant changes were observed between some of the treated groups and the controls. All these changes, however, were subtle and lacked any corresponding pathological findings. In addition, the increased or decreased values remained within the range of the historical control values. In fact, histopathological assessment revealed only sporadic and/or spontaneous lesions. In conclusion, the no-observed-adverse-effect-level (NOAEL) for l-Ser was, therefore, determined to be at least a dietary dose of 5.0% (2765.0 mg/kg body weight/day for males and 2905.1 mg/kg body weight/day for females) under the present experimental conditions.
对10只雄性和10只雌性Fischer 344大鼠进行了l-丝氨酸（l-Ser）的亚慢性喂养研究，将它们分为几组，分别喂食含0%、0.06%、0.5%、1.5%或5.0% l-Ser浓度的粉末状饲料，持续90天。在体重、食物摄入量、水摄入量或尿液分析数据方面，未观察到与处理相关的、具有毒理学意义的变化。在一些血液学、血清生物化学和器官重量参数方面，观察到一些处理组与对照组之间存在显著变化。然而，所有这些变化都很细微，且缺乏任何相应的病理学发现。此外，升高或降低的值仍在历史对照值范围内。事实上，组织病理学评估仅发现散在和/或自发的病变。因此，在当前实验条件下，确定l-丝氨酸的未观察到有害作用水平（NOAEL）至少为饮食剂量的5.0%（雄性为2765.0毫克/千克体重/天，雌性为2905.1毫克/千克体重/天）。
