初步研究：肝癌缺失基因1和磷酸化粘着斑激酶Y397在晚期上皮性卵巢癌中的表达变化及其预后价值
Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma.
作者信息
Fan Dong-Mei, Shi Hui-Rong
机构信息
Department of Obstetrics and Gynecology, First Affiliated Hospital, Zhengzhou University, No.1 Jianshe Road, Zhengzhou 450052, China.
出版信息
Int J Mol Sci. 2011;12(12):8489-501. doi: 10.3390/ijms12128489. Epub 2011 Nov 29.
BACKGROUND
Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles and prognostic values of their expression in epithelial ovarian carcinomas (EOCs) remain unclear.
METHODS
The expression and prognostic value of DLC1 and p-FAK Y397 in EOC were evaluated by immunohistochemistry and multivariate analysis.
RESULTS
Low expression of DLC1 and high expression of p-FAK Y397 were found in the 76 cases of EOC. The expression of DLC1 and p-FAK Y397 were negatively correlated. Multivariate analysis showed that the combination of them was an independent prognostic marker of EOC (P = 0.0319).
CONCLUSIONS
DLC1 and pFAK Y397 had an association with the clinicopathologic characteristics of EOC. Expression of neither of these genes was a prognostic factor alone, but the combination revealed a significant prognostic value in the 60 cases of advanced stage EOC.
背景
肝癌基因（DLC1）缺失和磷酸化粘着斑激酶（p-FAK）最近被报道为与转移相关的基因。然而，它们在上皮性卵巢癌（EOC）中的表达作用及预后价值仍不清楚。
方法
通过免疫组织化学和多因素分析评估DLC1和p-FAK Y397在EOC中的表达及预后价值。
结果
在76例EOC中发现DLC1低表达和p-FAK Y397高表达。DLC1和p-FAK Y397的表达呈负相关。多因素分析显示，它们的联合是EOC的独立预后标志物（P = 0.0319）。
结论
DLC1和pFAK Y397与EOC的临床病理特征有关。这两个基因单独表达均不是预后因素，但联合检测在60例晚期EOC中显示出显著的预后价值。
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