Wai Wong Chee, Dye Danielle E, Coombe Deirdre R
Molecular Immunology Group, School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University Level 3 MRF Building, Rear 50 Murray Street, Perth, WA 6000, Australia.
Int J Cell Biol. 2012;2012:340296. doi: 10.1155/2012/340296. Epub 2012 Jan 9.
Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes.
转移是一个主要的临床问题，也是大多数癌症预后不良的原因。转移途径描述了癌细胞在新的组织或器官中形成转移病灶的过程。它由相互关联的步骤组成，所有这些步骤都必须成功完成才能导致转移。细胞间粘附是其中许多步骤的一个关键方面。属于免疫球蛋白超家族（Ig-SF）的粘附分子通常在细胞间粘附中起核心作用，其中一些分子已与癌症进展和转移表型相关。令人惊讶的是，Ig-SF成员对转移的贡献尚未得到像整合素等其他细胞粘附分子（CAMs）那样的关注。在这里，我们研究转移途径中的各个步骤，重点关注Ig-SF成员，即黑色素瘤细胞粘附分子（MCAM）、L1细胞粘附分子（L1CAM）、神经细胞粘附分子（NCAM）、白细胞细胞粘附分子（ALCAM）、细胞间细胞粘附分子-1（ICAM-1）和血小板内皮细胞粘附分子-1（PECAM-1）如何发挥作用。尽管仍有许多有待了解的地方，但本综述旨在提高Ig-SF成员在转移形成中的关注度，并促使开展可能带来有益临床结果的进一步研究。
