Faa G, Gerosa C, Fanni D, Nemolato S, Marinelli V, Locci A, Senes G, Mais V, Van Eyken P, Iacovidou N, Monga G, Fanos V
Department of Pathology, Cagliari, Italy.
J Matern Fetal Neonatal Med. 2012 Jul;25(7):904-11. doi: 10.3109/14767058.2011.599457. Epub 2012 Jan 25.
CD10 was first identified in tumor cells of acute lymphoblastic leukemia. Most studies on CD10 expression have dealt with tumor pathology. Since no data are available for specific role in the fetal kidney, this study aimed at investigating CD10 expression during the different phases of renal embryogenesis. To this end, the expression of CD10 was evaluated in the kidney of two human fetus and in three newborns. In both fetuses, immunostaining for CD10 was compartmentalized and mainly concentrated in the mid-deep cortex. Reactivity for CD10 was stronger in the glomerular epithelium, in proximal tubules and in metanephric mesenchymal cells. At 25 weeks of gestation, CD10 was also detected in the subcapsular regions, including some pretubular aggregates of cap mesenchymal cells and renal vesicles. At 34 weeks of gestation, we observed an increased immunoreactivity for CD10 in visceral and parietal glomerular epithelium. At 39 weeks of gestation, CD10 was also expressed in the collecting tubules and in the Henle loops. Our data show a strong expression of CD10 in all stage of human kidney development, characterized by dynamic changes and support the hypothesis that CD10 plays a relevant role in renal embryogenesis.
CD10最初是在急性淋巴细胞白血病的肿瘤细胞中被发现的。大多数关于CD10表达的研究都涉及肿瘤病理学。由于目前尚无关于其在胎儿肾脏中具体作用的数据，本研究旨在调查CD10在肾脏胚胎发育不同阶段的表达情况。为此，对两名人类胎儿和三名新生儿的肾脏中CD10的表达进行了评估。在这两名胎儿中，CD10的免疫染色呈分区化，主要集中在皮质中深层。CD10在肾小球上皮、近端小管和后肾间充质细胞中的反应更强。在妊娠25周时，在被膜下区域也检测到CD10，包括一些帽状间充质细胞和肾小泡的肾小管前聚集体。在妊娠34周时，我们观察到肾小球脏层和壁层上皮中CD10的免疫反应性增加。在妊娠39周时，CD10也在集合小管和髓袢中表达。我们的数据显示CD10在人类肾脏发育的所有阶段均有强烈表达，其特征为动态变化，并支持CD10在肾脏胚胎发育中发挥相关作用这一假说。
