Guo Hongchao, Ding Kuiling
Department of Applied Chemistry China Agricultural University 2 Yuanmingyuan West Road, Beijing 100193, China.
Chimia (Aarau). 2011;65(12):932-8. doi: 10.2533/chimia.2011.932.
A conceptually new strategy for chiral catalyst immobilization, self-supported catalysts, in heterogeneous asymmetric catalysis is highlighted in the present article. Various homochiral metal-organic polymers with diverse structures have been designed and readily prepared through coordination assembly of modular polytypic/polyfunctional ligands and metal ions without using any supports. These polymers have been successfully employed as chiral catalysts in a variety of heterogeneous asymmetric ractions, including hydrogenation, epoxidation, sulfoxidation, carbonyl-ene reactions, diethylzinc addition, and Michael addition. The self-supported heterogeneous chiral catalysts showed activity and enanioselectivity comparable or even superior to those obtained with their corresponding homogeneous counterparts, and could be readily recovered and reused several times without significant loss of activity or enantioslectivity.
本文重点介绍了一种非均相不对称催化中手性催化剂固定化的全新概念策略——自负载催化剂。通过模块化多型/多功能配体与金属离子的配位组装，无需使用任何载体，即可轻松设计并制备出各种结构各异的手性金属有机聚合物。这些聚合物已成功用作多种非均相不对称反应中的手性催化剂，包括氢化反应、环氧化反应、硫氧化反应、羰基-烯反应、二乙基锌加成反应和迈克尔加成反应。自负载非均相手性催化剂表现出的活性和对映选择性与相应的均相催化剂相当，甚至更优，并且可以轻松回收并重复使用多次，而活性或对映选择性不会有显著损失。
