University of São Paulo School of Medicine, São Paulo, SP, Brazil.
J Glaucoma. 2013 Jun-Jul;22(5):390-2. doi: 10.1097/IJG.0b013e3182447a03.
To verify the reproducibility of the mean, peak, and fluctuation of intraocular pressure (IOP) observed during modified diurnal tension curves (mDTC) performed on ocular hypertensive and primary open-angle glaucoma patients.
Prospective analysis of 88 eyes from 88 ocular hypertensive and primary open-angle glaucoma patients subjected to 2 consecutive mDTCs (IOP measurements obtained at 8:00 AM, 11:00 AM, 2:00 PM, and 4:00 PM) on 2 consecutive days. Mean IOP was calculated as the average of all IOP measurements obtained during each mDTC. Peak and minimum IOP levels were considered as the highest and lowest IOP level during each mDTC, respectively. IOP fluctuation was calculated using 2 different approaches: the difference between IOP peak and minimum IOP detected during each mDTC and as the SD of all mDTC measurements. Reproducibility was assessed using the intraclass correlation coefficient (ICC).
IOP fluctuation between 2 days in the modified diurnal curve, calculated as the difference between peak IOP and minimum IOP and as the SD of all mDTC measurements, was less reproducible than the mean IOP and peak IOP (ICC values 0.60, 0.62, 0.91, and 0.85, respectively; all ICC values, P<0.001).
Mean IOP and peak IOP observed during the mDTC had good reproducibility, whereas the reproducibility of IOP fluctuation was only fair.
验证在高眼压症和原发性开角型青光眼患者中进行改良日间眼压曲线（mDTC）时观察到的眼压（IOP）平均值、峰值和波动的可重复性。
对 88 例高眼压症和原发性开角型青光眼患者的 88 只眼进行了前瞻性分析，这些患者连续两天进行了 2 次 mDTC（分别于上午 8 点、上午 11 点、下午 2 点和下午 4 点测量 IOP）。平均 IOP 是在每次 mDTC 期间获得的所有 IOP 测量值的平均值。峰值和最小 IOP 水平分别被视为每次 mDTC 期间的最高和最低 IOP 水平。IOP 波动使用 2 种不同方法计算：每次 mDTC 期间检测到的 IOP 峰值和最小 IOP 之间的差异以及所有 mDTC 测量值的 SD。使用组内相关系数（ICC）评估可重复性。
改良日间曲线 2 天之间的 IOP 波动（作为每次 mDTC 期间的峰值 IOP 和最小 IOP 之间的差异以及所有 mDTC 测量值的 SD 计算）的可重复性低于平均 IOP 和峰值 IOP（ICC 值分别为 0.60、0.62、0.91 和 0.85；所有 ICC 值，P<0.001）。
mDTC 期间观察到的平均 IOP 和峰值 IOP 具有良好的可重复性，而 IOP 波动的可重复性仅为中等。
