Women's Health Research Center, Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Hypertension. 2012 Mar;59(3):726-31. doi: 10.1161/HYPERTENSIONAHA.111.180943. Epub 2012 Jan 23.
Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone levels were significantly decreased. Testosterone supplements increased plasma levels, 10-fold in both obese Zucker rats and lean Zucker rats. In obese Zucker rats, testosterone supplements reduced body weight, plasma insulin, and cholesterol levels and improved the oral glucose tolerance test. None of these parameters were affected in lean Zucker rats. Mean arterial pressure was significantly increased in obese Zucker rats but not lean Zucker rats. Testosterone supplements increased proteinuria and accelerated renal injury in lean Zucker rats only. Thus, treatment of obese men with chronic testosterone supplements should be done with careful monitoring of blood pressure.
与体重正常的个体相比，肥胖男性的雄激素水平较低。然而，目前尚无关于中年男性长期使用雄激素补充剂的安全性数据。本研究旨在确定从 22 周龄开始（此时睾酮水平显著降低），对雄性肥胖 Zucker 大鼠进行慢性（10 周）睾酮治疗对心血管和代谢的影响。肥胖 Zucker 大鼠和瘦 Zucker 大鼠的血浆水平均增加了 10 倍。在肥胖 Zucker 大鼠中，睾酮补充剂降低了体重、血浆胰岛素和胆固醇水平，并改善了口服葡萄糖耐量试验。这些参数在瘦 Zucker 大鼠中均不受影响。肥胖 Zucker 大鼠的平均动脉压显著升高，但瘦 Zucker 大鼠没有。只有在瘦 Zucker 大鼠中，睾酮补充剂增加了蛋白尿并加速了肾脏损伤。因此，对肥胖男性进行慢性睾酮补充治疗时，应密切监测血压。
