Department of Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, Jackson, USA.
Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
J Biomed Sci. 2018 Dec 3;25(1):89. doi: 10.1186/s12929-018-0488-3.
Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific mechanisms of this disease are unknown. Consequently, there is any particular treatment according to the sex/gender at this time. During the last decade, we observe a rise in the study of adipocyte and the possible mechanisms involved in the different roles of the fat. Furthermore, the effect of sex steroids on the adipocyte is one of the fields that need elucidation. Supporting evidence suggests that sex steroids play an essential role not only in the fat distribution, but also, in its metabolism, proliferation, and function. Thus, using in vitro and in vivo studies will contribute to our fight against this critical health public problem encompassing both sexes. In the present review, we discuss some of the recent advances in the adipocytes and the effect of the sex steroids on the adipose tissue. Also, we propose a new alternative to study the role of sex steroids on adipocyte biology through human adipose-derived stem cells.
肥胖症是美国最具危害性和可预防的疾病之一。越来越多的证据表明，人类和实验动物的肥胖存在性别差异。然而，这种疾病的确切机制尚不清楚。因此，目前没有针对性别/性别的特定治疗方法。在过去的十年中，我们观察到人们对脂肪细胞的研究以及可能涉及到脂肪不同作用的机制的增加。此外，性激素对脂肪细胞的影响是需要阐明的领域之一。有证据表明，性激素不仅在脂肪分布中起着重要作用，而且在脂肪代谢、增殖和功能中也起着重要作用。因此，使用体外和体内研究将有助于我们对抗这一对两性都有影响的重大公共卫生问题。在本综述中，我们讨论了脂肪细胞的一些最新进展，以及性激素对脂肪组织的影响。此外，我们还提出了一种通过人脂肪源性干细胞研究性激素对脂肪细胞生物学作用的新方法。
