Wemmie John A
Department of Psychiatry, Interdisciplinary Graduate Program in Neuroscience, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Dialogues Clin Neurosci. 2011;13(4):475-83. doi: 10.31887/DCNS.2011.13.4/jwemmie.
Panic disorder is a common and disabling illness for which treatments are too frequently ineffective. Greater knowledge of the underlying biology could aid the discovery of better therapies. Although panic attacks occur unpredictably, the ability to provoke them in the laboratory with challenge protocols provides an opportunity for crucial insight into the neurobiology of panic. Two of the most well-studied panic provocation challenges are CO(2) inhalation and lactate infusion. Although it remains unclear how these challenges provoke panic animal models of CO(2) and lactate action are beginning to emerge, and offer unprecedented opportunities to probe the molecules and circuits underlying panic attacks. Both CO(2) and lactate alter pH balance and may generate acidosis that can influence neuron function through a growing list of pH-sensitive receptors. These observations suggest that a key to better understanding of panic disorder may He in more knowledge of brain pH regulation and pH-sensitive receptors.
惊恐障碍是一种常见且使人致残的疾病，其治疗常常无效。对潜在生物学机制有更多了解有助于发现更好的治疗方法。尽管惊恐发作不可预测，但在实验室中通过激发方案诱发惊恐发作的能力为深入了解惊恐的神经生物学提供了关键契机。两种研究最充分的惊恐激发挑战是吸入二氧化碳和输注乳酸盐。虽然尚不清楚这些挑战如何诱发惊恐，但二氧化碳和乳酸盐作用的动物模型已开始出现，并为探究惊恐发作背后的分子和神经回路提供了前所未有的机会。二氧化碳和乳酸盐都会改变pH平衡，并可能产生酸中毒，进而通过越来越多的pH敏感受体影响神经元功能。这些观察结果表明，更好地理解惊恐障碍的关键可能在于更深入了解大脑pH调节和pH敏感受体。
