Gadoth Natan
Department of Neurology, Maynei Hayeshua Medical Center, Bnei Barak 54417 and the Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Brain Dev. 2012 Oct;34(9):705-11. doi: 10.1016/j.braindev.2011.12.008. Epub 2012 Jan 24.
Subacute sclerosing panencephalitis (SSPE), is a devastating "slow virus" brain disease which affects young children who had measles some 6-7 years earlier. Although, the pandemic of SSPE during 1960-1980's was almost eradicated due to mass immunization, the disease is still taking the life of young children in countries where measles immunization is incomplete and in world regions where genetic polymorphism to this particular infection is present. The present review was written for the fortunate young generation of pediatricians and pediatric neurologists who probably have not seen a case of SSPE during their career, and for those who work in counties where the disease has not been eradicated. It is also a reminder that with full coverage of measles immunization this devastating disease can be fully eradicated.
亚急性硬化性全脑炎（SSPE）是一种极具破坏性的“慢病毒”脑部疾病，影响约6 - 7年前患过麻疹的幼儿。尽管由于大规模免疫接种，20世纪60年代至80年代期间的SSPE大流行几乎被根除，但在麻疹免疫接种不完全的国家以及存在针对这种特定感染的基因多态性的世界地区，这种疾病仍在夺走幼儿的生命。本综述是为那些幸运的年轻一代儿科医生和儿科神经科医生而写，他们在职业生涯中可能从未见过SSPE病例，也是为那些在该疾病尚未根除的国家工作的人而写。这也提醒人们，通过全面覆盖麻疹免疫接种，这种毁灭性疾病可以被完全根除。
