Xu Ting, Xu Zi-Cheng, Zou Qin, Yu Bin, Huang Xin-En
Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province, Nanjing Medical University, Nanjing, China.
Asian Pac J Cancer Prev. 2012;13(5):2349-54. doi: 10.7314/apjcp.2012.13.5.2349.
Individual studies of the associations between P53 codon 72 polymorphism (rs1042522) and bladder cancer susceptibility have shown inconclusive results. To derive a more precise estimation of the relationship, we performed this systemic review and meta-analysis based on 15 publications.
We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.
We found that there was no association between P53 codon 72 polymorphism and bladder cancer risk in the comparisons of Pro/ Pro vs Arg/Arg; Pro/Arg vs. Arg/Arg; Pro/Pro plus Pro/Arg vs. Arg/Arg; Arg/Arg vs. Pro/Arg plus Arg/Arg (OR=1.06 95%CI 0.81-1.39; OR=1.06 95%CI 0.83-1.36; OR=0.98 95%CI 0.78-1.23; OR=1.06 95%CI 0.84-1.32). However, a significantly increased risk of bladder cancer was found among Asians in the homozygote comparison (Pro/Pro vs. Arg/Arg, OR=1.36 95%CI 1.05-1.75, P=0.790 for heterogeneity) and the dominant model (Arg/Pro plus Pro/Pro vs. Arg/Arg, OR=1.26 95%CI 1.05-1.52, P=0.564 for heterogeneity). In contrast, no evidence of an association between bladder cancer risk and P53 genotype was observed among Caucasian population in any genetic model. When stratifying for the stage of bladder, no statistical association were found (Pro/Pro vs. Arg/Arg, OR=0.45 95%CI 0.17-1.21; Pro/Arg vs. Arg/Arg, OR=0.60 95%CI 0.28-1.27; Dominant model, OR=0.56 95%CI 0.26-1.20; Recessive model, OR=0.62 95%CI 0.35-1.08) between P53 codon 72 polymorphism and bladder cancer in all comparisons.
Despite the limitations, the results of the present meta-analysis suggest that, in the P53 codon 72, Pro/Pro type and dominant mode might increase the susceptibility to bladder cancer in Asians; and there are no association between genotype distribution and the stage of bladder cancer.
关于P53基因第72位密码子多态性（rs1042522）与膀胱癌易感性之间关联的个别研究结果尚无定论。为更精确地评估二者关系，我们基于15篇文献进行了此项系统评价和荟萃分析。
我们采用比值比（OR）及95%置信区间（CI）来评估关联强度。
在Pro/Pro与Arg/Arg、Pro/Arg与Arg/Arg、Pro/Pro加Pro/Arg与Arg/Arg、Arg/Arg与Pro/Arg加Arg/Arg的比较中，我们发现P53基因第72位密码子多态性与膀胱癌风险之间无关联（OR = 1.06，95%CI 0.81 - 1.39；OR = 1.06，95%CI 0.83 - 1.36；OR = 0.98，95%CI 0.78 - 1.23；OR = 1.06，95%CI 0.84 - 1.32）。然而，在纯合子比较（Pro/Pro与Arg/Arg，OR = 1.36，95%CI 1.05 - 1.75，异质性P = 0.790）和显性模型（Arg/Pro加Pro/Pro与Arg/Arg，OR = 1.26，95%CI 1.05 - 1.52，异质性P = 0.564）中，亚洲人患膀胱癌的风险显著增加。相比之下，在任何遗传模型中，白种人群中均未观察到膀胱癌风险与P53基因型之间存在关联的证据。按膀胱癌分期进行分层时，在所有比较中，未发现P53基因第72位密码子多态性与膀胱癌之间存在统计学关联（Pro/Pro与Arg/Arg，OR = 0.45，95%CI 0.17 - 1.21；Pro/Arg与Arg/Arg，OR = 0.60，95%CI 0.28 - 1.27；显性模型，OR = 0.56，95%CI 0.26 - 1.20；隐性模型，OR = 0.62，95%CI 0.35 - 1.08）。
尽管存在局限性，但本荟萃分析结果表明，在P53基因第72位密码子中，Pro/Pro型和显性模式可能会增加亚洲人患膀胱癌的易感性；且基因型分布与膀胱癌分期之间无关联。
