State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
Phytochemistry. 2012 Apr;76:124-32. doi: 10.1016/j.phytochem.2012.01.004. Epub 2012 Jan 23.
Cycloartane-type triterpenoids (1-3), seven sesquiterpenoids (7-13), and five previously reported secondary metabolites, including three cycloartane-type triterpenoids (4-6) and two sesquiterpenoids (14 and 15), were isolated from the resinous exudates of Commiphora opobalsamum. Their structures were elucidated by extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. The structures of 1, 3, and 7 were confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of 1 was interpreted by the incorporation of CHCl(3) (crystallization solvent) in the crystal and that of 10 was determined by the CD exciton chirality method. Compound 12 represents the first example of a 12-norcadinane-type sesquiterpenoid. Furthermore, compounds 1, 3, 7, and 10-14 were evaluated for cytotoxicity against HeLa and HepG2 cell lines.
环阿尔廷型三萜（1-3）、7 种倍半萜（7-13）和 5 种以前报道的次生代谢产物，包括 3 种环阿尔廷型三萜（4-6）和 2 种倍半萜（14 和 15），从乳香树脂状渗出物中分离得到。通过广泛的光谱分析，包括 UV、IR、NMR 和 MS，并与文献数据进行比较，确定了它们的结构。通过单晶 X 射线衍射分析确定了 1、3 和 7 的结构。通过 CHCl3（结晶溶剂）在晶体中的掺入确定了 1 的绝对构型，通过 CD 激子手性法确定了 10 的绝对构型。化合物 12 代表了第一个 12-降卡达烷型倍半萜。此外，对化合物 1、3、7 和 10-14 进行了对 HeLa 和 HepG2 细胞系的细胞毒性评估。
