来自绒毛苹婆的环阿尔廷烷三萜类化合物。

Cycloartane triterpenoids from Kleinhovia hospita.

作者信息

Gan Li-She, Ren Gang, Mo Jian-Xia, Zhang Xiang-Yi, Yao Wei, Zhou Chang-Xin

机构信息

Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.

出版信息

J Nat Prod. 2009 Jun;72(6):1102-5. doi: 10.1021/np900029z.

DOI:10.1021/np900029z

PMID:19489592

Abstract

Four new cycloartane triterpenoids, together with the known gardenolic acid B, were isolated from Kleinhovia hospita. The triterpenoids (1-3) contain a unique 21,23-diacetal side-chain, while compound 4 contains two alpha,beta-unsaturated ketone moieties. Their structures and relative configurations were determined by spectroscopic methods, including 2D NMR and IR. These compounds showed promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

摘要

从异木棉中分离出四种新的环阿尔廷烷三萜类化合物，以及已知的园林酸B。这些三萜类化合物（1-3）含有独特的21,23-二缩醛侧链，而化合物4含有两个α,β-不饱和酮基团。它们的结构和相对构型通过光谱方法确定，包括二维核磁共振和红外光谱。这些化合物对呋喃妥因诱导的人肝源性Hep G2细胞的细胞毒性显示出有前景的肝保护作用。