College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
Planta Med. 2011 Dec;77(18):2023-8. doi: 10.1055/s-0031-1280087. Epub 2011 Aug 9.
Ten new furanosesquiterpenoids, myrrhterpenoids A-J (1- 10), together with eight known analogues (11- 18), were isolated from the resinous exudates of COMMIPHORA MYRRHA. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP (+)-induced neuronal cell death in SH-SY5Y cells.
从乳香树的树脂分泌物中分离得到了 10 个新的呋喃倍半萜类化合物，乳香萜烯 A-J（1-10），以及 8 个已知类似物（11-18）。通过光谱方法（IR、ESIMS、HRESIMS、1D 和 2D NMR）和使用 MM2 的 ChemDraw 3D 建模阐明了它们的结构和相对构型。所有分离出的呋喃倍半萜类化合物均显示出对 MPP (+)-诱导的 SH-SY5Y 细胞神经元细胞死亡的神经保护作用。
