Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow, India.
J Headache Pain. 2012 Jun;13(4):321-6. doi: 10.1007/s10194-012-0416-y. Epub 2012 Jan 26.
Metabolic syndrome is associated with migraine but there is no study comparing the characteristics of migraine with and without metabolic syndrome from Southeast Asia. This study was therefore undertaken to compare the clinical characteristics of migraine in patients with and without metabolic syndrome and insulin resistance. 135 consecutive patients with migraine diagnosed on the basis of International Headache Society criteria were subjected to clinical evaluation as per fixed protocol. Headache severity, frequency and functional disability were recorded. Metabolic syndrome was diagnosed as per National Cholesterol Education Programme: Adult Treatment Panel III and International Diabetic Federation criteria. Insulin resistance was calculated by homeostases model assessment. Their age ranged between 14 and 61 years and 108 were females. Metabolic syndrome was present in 31.9% patients and only 13 were obese. Insulin resistance was present in 11.1%. Metabolic syndrome was correlated with age, gender, number of triggers, years of headache and duration of migraine attacks. Insulin resistance correlated with duration of migraine attacks. From this study, it can be concluded that metabolic syndrome was present in 31.9% of the migraineurs which was mainly in elderly who had longer duration of headache and multiple triggers.
代谢综合征与偏头痛有关，但目前尚无研究比较来自东南亚的有代谢综合征和无代谢综合征的偏头痛特征。因此，本研究旨在比较有和无代谢综合征及胰岛素抵抗的偏头痛患者的临床特征。根据国际头痛协会标准诊断的 135 例连续偏头痛患者按照固定方案进行临床评估。记录头痛严重程度、频率和功能障碍。代谢综合征按国家胆固醇教育计划：成人治疗小组 III 和国际糖尿病联合会标准诊断。用稳态模型评估法计算胰岛素抵抗。他们的年龄在 14 岁至 61 岁之间，其中 108 人为女性。31.9%的患者存在代谢综合征，只有 13 人肥胖。11.1%的患者存在胰岛素抵抗。代谢综合征与年龄、性别、触发因素数量、头痛年限和偏头痛发作持续时间有关。胰岛素抵抗与偏头痛发作持续时间有关。从这项研究可以得出结论，代谢综合征在偏头痛患者中的发生率为 31.9%，主要发生在年龄较大、头痛持续时间较长和有多个触发因素的患者中。
