Trubnikova Olga, Tarasova Irina, Barbarash Olga
Department of Multifocal Atherosclerosis, Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences Kemerovo, Russian Federation.
Front Neurol. 2012 Jan 18;3:1. doi: 10.3389/fneur.2012.00001. eCollection 2012.
Significant (>70%) extracranial stenosis of the internal carotid artery (ICA) is a known risk factor for brain damage in patients with coronary heart disease (CHD) undergoing coronary artery bypass grafting (CABG). There is no clear evidence of the low and moderate ICA stenoses influence on the neurophysiologic status of patients after CABG. This work was aimed at studying the influence ICA stenoses (<50%) on the dynamics of neurophysiologic status in patients undergone CABG.
We examined neurophysiologic functions and electroencephalograph in CHD patients (N = 45) aged from 45 to 70 years. All patients were divided into two groups: with ICA stenosis (n = 20) and without one (n = 25).
It was established that the group ICA stenosis had a negative dynamics of neurophysiologic status 6 months follow-up after CABG compared with patients without stenosis.
Our results suggest that the presence of low and moderate ICA stenosis is one of the factors affecting the neurophysiologic status of CHD patients. It has been assumed that the patients with ≤50% ICA stenoses constitute a high-risk group for cerebral complications after on-pump CABG.
颈内动脉（ICA）颅外段严重狭窄（>70%）是冠心病（CHD）患者行冠状动脉旁路移植术（CABG）时脑损伤的已知危险因素。目前尚无明确证据表明ICA轻度和中度狭窄对CABG术后患者神经生理状态有影响。本研究旨在探讨ICA狭窄（<50%）对CABG术后患者神经生理状态动态变化的影响。
我们对45至70岁的CHD患者（N = 45）进行了神经生理功能和脑电图检查。所有患者分为两组：有ICA狭窄组（n = 20）和无ICA狭窄组（n = 25）。
与无狭窄患者相比，CABG术后6个月随访发现，ICA狭窄组患者神经生理状态呈负向动态变化。
我们的结果表明，ICA轻度和中度狭窄是影响CHD患者神经生理状态的因素之一。据推测，ICA狭窄≤50%的患者是体外循环下CABG术后发生脑并发症的高危人群。
