Croy B Anne, Burke Suzanne D, Barrette Valerie F, Zhang Jianhong, Hatta Kota, Smith Graeme N, Bianco Juares, Yamada Aureo T, Adams Michael A
Department of Anatomy and Cell Biology, Queen's University, Kingston ON Canada K7L 3N6.
Pregnancy Hypertens. 2011 Jan 1;1(1):87-94. doi: 10.1016/j.preghy.2010.10.002.
Pre-eclampsia, an acute complication of human pregnancy, is associated within complete physiological modification of decidual spiral arteries. This is thought to promote oxidative stress from perfusion/reperfusion of the placenta and to restrict placental and fetal growth. Alymphoid (genotype Rag2(-/-)/Il2rg(-/-)) mice, sufficient in dendritic and myeloid cell functions, lack spiral arterial modification with individual spiral arteries having ~1.7x the vascular resistance and 0.66x the blood velocity of +/+ mice. Their placentae are measurably hypoxic yet neither placental growth nor fetal survival is impaired and gestational hypertension is not seen. Thus, lymphocytes rather than vascular adaptations appear to be the pivotal contributors to the clinical complications of pre-eclampsia.
子痫前期是人类妊娠的一种急性并发症，与蜕膜螺旋动脉的完全生理改变有关。据认为，这会促进胎盘灌注/再灌注产生的氧化应激，并限制胎盘和胎儿的生长。无淋巴细胞（基因型Rag2(-/-)/Il2rg(-/-)）小鼠的树突状细胞和髓样细胞功能正常，但缺乏螺旋动脉改变，其单个螺旋动脉的血管阻力约为+/+小鼠的1.7倍，血流速度为+/+小鼠的0.66倍。它们的胎盘有明显的缺氧，但胎盘生长和胎儿存活均未受损，也未见妊娠期高血压。因此，淋巴细胞而非血管适应性似乎是子痫前期临床并发症的关键因素。
