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子宫自然杀伤细胞异质性：来自小鼠模型的启示。

Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models.

机构信息

Rheumatology Division, Washington University School of Medicine, St. Louis, MO, United States.

出版信息

Front Immunol. 2020 Feb 21;11:290. doi: 10.3389/fimmu.2020.00290. eCollection 2020.

DOI:10.3389/fimmu.2020.00290
PMID:32153593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7046796/
Abstract

Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.

摘要

自然杀伤 (NK) 细胞是母胎界面上最丰富的淋巴细胞。流行病学数据表明 NK 细胞与人类妊娠结局有关。使用小鼠 NK 细胞的发现指导了随后人类 NK 细胞生物学的进展。然而，由于怀孕期间全身内分泌和局部子宫结构微环境的动态变化，仍然难以确定小鼠和人类子宫 NK(uNK) 细胞的功能。本文讨论了母胎界面小鼠和人类 NK 细胞的功能相似性和差异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee38/7046796/20e31553434a/fimmu-11-00290-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee38/7046796/d4753b4234c5/fimmu-11-00290-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee38/7046796/20e31553434a/fimmu-11-00290-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee38/7046796/d4753b4234c5/fimmu-11-00290-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee38/7046796/20e31553434a/fimmu-11-00290-g0002.jpg

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本文引用的文献

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Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.妊娠早期人蜕膜中固有淋巴细胞的独特表型和功能。
Nat Commun. 2020 Jan 20;11(1):381. doi: 10.1038/s41467-019-14123-z.
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infection drives conversion of NK cells into ILC1-like cells.感染促使 NK 细胞向 ILC1 样细胞转化。
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Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.Gab3 对于 IL-2 和 IL-15 诱导的 NK 细胞扩增是必需的，并限制妊娠期间滋养层的侵袭。
NK cell exhaustion in the tumor microenvironment.
肿瘤微环境中的 NK 细胞耗竭。
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Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes.血管黏附蛋白-1决定子宫内膜周细胞的细胞特性。
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Front Immunol. 2020 Aug 11;11:1945. doi: 10.3389/fimmu.2020.01945. eCollection 2020.
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Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance.组织驻留自然杀伤细胞：发育、成熟及临床意义
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Immune responses at the maternal-fetal interface.母体-胎儿界面的免疫反应。
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