具有选择性抑制肾癌细胞生长的氯化恩格尔菌素。
Chlorinated englerins with selective inhibition of renal cancer cell growth.
机构信息
Natural Products Support Group, SAIC-Frederick National Cancer Institute, Frederick, Maryland 21702, United States.
出版信息
J Nat Prod. 2012 Mar 23;75(3):459-63. doi: 10.1021/np200905u. Epub 2012 Jan 26.
Abstract
The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).
摘要
从 Phyllanthus engleri 中分离得到的氯化埃格林（3-9）被证明能选择性地抑制肾癌细胞的生长。这些化合物被证明是在分离过程中暴露于氯仿分解产物而产生的提取副产物。最具活性的化合物 3 是由埃格林 A（1）合成得到的。
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