Fash David M, Peer Cody J, Li Zhenwu, Talisman Ian J, Hayavi Sima, Sulzmaier Florian J, Ramos Joe W, Sourbier Carole, Neckers Leonard, Figg W Douglas, Beutler John A, Chain William J
Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States.
Genitourinary Malignancies Branch, National Cancer Institute, Frederick, MD 21702, United States.
Bioorg Med Chem Lett. 2016 Jun 1;26(11):2641-4. doi: 10.1016/j.bmcl.2016.04.016. Epub 2016 Apr 8.
Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.
合成了乙醇酸部分水解倾向降低的恩格勒菌素A类似物，得到了一种具有母体肾癌细胞选择性且在小鼠体内可口服生物利用的化合物。
