Tuomisto J, Vartiainen T
Department of Environmental Hygiene and Toxicology, National Institute of Public Health, Kuopio, Finland.
IARC Sci Publ. 1990(104):307-13.
Drinking waters in many countries have been shown to contain non-volatile polar mutagenic compounds as well as trihalomethanes. Their nature is uncertain, but one compound, a chlorinated furanone (3-chloro-4-(dichloro-methyl)-5-hydroxy-2(5H)-furanone;MX) seems to be responsible for one third to over one half of the mutagenicity. Its concentration seems to correlate rather well also with the total bacterial mutagenicity. Animal toxicity studies are being used to evaluate the possible carcinogenicity risk of this compound as a first stage in complete risk assessment of the whole complex mixture. Epidemiological risk assessment is also possible, since mutagenicity values can be predicted on the basis of organic material in the raw water and the amount of chlorine used. This information has been collected in Finland retrospectively from waterworks, and will be correlated with the Finnish Cancer Registry data.
许多国家的饮用水已被证明含有非挥发性极性诱变化合物以及三卤甲烷。它们的性质尚不确定，但有一种化合物，即氯化呋喃酮（3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮；MX）似乎导致了三分之一至超过一半的致突变性。其浓度似乎也与总细菌致突变性有较好的相关性。动物毒性研究正被用作评估该化合物潜在致癌风险的手段，这是对整个复杂混合物进行全面风险评估的第一阶段。流行病学风险评估也是可行的，因为可以根据原水中的有机物质和所用氯的量来预测致突变性值。这些信息已在芬兰从自来水厂进行了回顾性收集，并将与芬兰癌症登记处的数据进行关联。
