评论“dpp 信号转导与增殖控制动力学”一文。

Comment on "Dynamics of dpp signaling and proliferation control".

机构信息

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

出版信息

Science. 2012 Jan 27;335(6067):401; author reply 401. doi: 10.1126/science.1210997.

Abstract

Wartlick et al. (Research Articles, 4 March 2011, p. 1154) reported that growth rates in the Drosophila wing disc correlate with increasing Dpp signaling levels, suggesting that the rate of Dpp increase determines the cell-cycle length. Contradicting their model, we found that cells in which the increase of Dpp signaling levels was genetically abrogated grew at rates comparable to those of wild-type cells.

摘要

wartlick 等人（研究文章，2011 年 3 月 4 日，第 1154 页）报道，果蝇翅盘中的生长速度与 Dpp 信号水平的增加相关，表明 Dpp 增加的速度决定了细胞周期的长度。与他们的模型相反，我们发现，遗传上消除 Dpp 信号水平增加的细胞的生长速度与野生型细胞相当。