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一种用于在活细胞中检测和成像超氧阴离子自由基的高选择性和高灵敏度的纳米探针。

A highly selective and sensitive nanoprobe for detection and imaging of the superoxide anion radical in living cells.

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, PR China.

出版信息

Chem Commun (Camb). 2012 Mar 4;48(19):2507-9. doi: 10.1039/c2cc16376d. Epub 2012 Jan 27.

DOI:10.1039/c2cc16376d
PMID:22282818
Abstract

A novel fluorescent nanoprobe with high sensitivity and selectivity for detection and imaging of the superoxide anion radical O(2)(·-) in living cells was designed and synthesized by a simple self-assembly method based on 2-chloro-1,3-dibenzothiazoline-cyclohexene (DBZTC) and Ag@SiO(2) core-shell nanoparticles.

摘要

设计并合成了一种新型的荧光纳米探针,该探针基于 2-氯-1,3-二苯并噻唑啉-环已烯(DBZTC)和 Ag@SiO2 核壳纳米粒子,通过简单的自组装方法,具有高灵敏度和选择性,可用于检测和成像活细胞中的超氧阴离子自由基 O(2)(·-)。

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