Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Clin Sci (Lond). 2012 May 1;122(10):439-47. doi: 10.1042/CS20110159.
MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches.
人类和哺乳动物模式生物中的 microRNA 研究正处于关键的发展阶段。microRNAs 的诊断和治疗价值似乎很有前景，但仍有待确立。microRNAs 的生理和病理生理意义已得到普遍认可，但在某些器官系统和疾病领域的理解要好于其他领域。在本文中，我们回顾了几项 microRNAs 的转化研究，包括那些显示靶向 microRNAs 的治疗剂和可在体液中检测到的诊断或预后 microRNA 标志物具有潜在价值的研究。我们讨论了从这些研究中吸取的经验教训。最近的几项研究已经开始探索肾脏疾病和高血压中的转化 microRNA 研究。肾脏中的 microRNA 转化研究面临着独特的挑战，但也提供了许多机会来开发和应用新方法，并融合互补的基础和临床方法。
