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来自毛叶锡生藤的具有降血糖活性的克罗烷二萜类化合物。

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.

作者信息

Gao Yuan, Niu Yan-Fen, Wang Fei, Hai Ping, Wang Fang, Fang Yin-Dong, Xiong Wen-Yong, Liu Ji-Kai

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.

Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2016 Oct;6(5):247-255. doi: 10.1007/s13659-016-0109-3. Epub 2016 Oct 17.

DOI:10.1007/s13659-016-0109-3
PMID:27752986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5080211/
Abstract

Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

摘要

从毛叶锡生藤的藤茎中分离得到4个新的克罗烷二萜类化合物，锡生藤醇A-C（2-4）和锡生藤苷A（5），以及6个已知类似物。通过广泛的光谱分析确定了它们的结构。借助分子模型首次确定了该植物主要成分、已知二萜类化合物波拉坡苷E（1）中C-12位的相对构型。化合物1在四氧嘧啶诱导的高血糖小鼠和db/db 2型糖尿病小鼠中，以剂量依赖性方式显著降低血清葡萄糖水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/37806f418295/13659_2016_109_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/583dd0f0348a/13659_2016_109_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/e8f255aa5fdb/13659_2016_109_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/e2a2d060218e/13659_2016_109_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/37806f418295/13659_2016_109_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/583dd0f0348a/13659_2016_109_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/e8f255aa5fdb/13659_2016_109_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/e2a2d060218e/13659_2016_109_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f991/5080211/37806f418295/13659_2016_109_Fig4_HTML.jpg

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