Laboratory of Chemistry and Electrochemistry of Surfaces, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium.
J Colloid Interface Sci. 2012 Apr 1;371(1):150-8. doi: 10.1016/j.jcis.2011.12.066. Epub 2012 Jan 8.
Nowadays, titanium is a very commonly used biomaterial for the preparation of orthopedic and dental implants. Its excellent mechanical and biochemical bulk properties are nevertheless counterbalanced by its propensity to long term degradation in physiological conditions and its weak osseointegrative capacities. In this context, surface modifications can significantly hinder titanium weaknesses. The approach considered in this work relies on the preparation of thin composite coatings based on tantalum oxide and carbon nanotubes by sol-gel process. Tantalum is particularly interesting for its high biocompatibility and bioactivity, as well as its strong resistance to bio-corrosion. Carbon nanotubes are exploited to reinforce the compactness and homogeneity of the coatings, and can act as a favorable factor to strengthen the interaction with bone components by biomimicry. The composite layers are further modified with specific organophosphonic acid molecular films, able to chemically bind the tantalum oxide surface and improve the hydroxyapatite formation process. The characteristics and the qualities of these hybrid inorganic/organic coatings are evaluated by XPS, SEM, TEM, peeling tests, contact angle measurements, and electrochemical characterizations (free potential, polarization curves).
如今，钛是一种非常常用的生物材料，用于制备骨科和牙科植入物。然而，其优异的机械和生化整体性能被其在生理条件下长期降解的倾向和较弱的骨整合能力所抵消。在这种情况下，表面改性可以显著阻碍钛的弱点。本工作所考虑的方法依赖于通过溶胶-凝胶工艺制备基于氧化钽和碳纳米管的薄复合涂层。钽因其高生物相容性和生物活性以及对生物腐蚀的强抵抗力而特别有趣。碳纳米管被用来增强涂层的致密性和均匀性，并可以通过仿生作用作为增强与骨成分相互作用的有利因素。复合层进一步用特定的有机膦酸分子膜进行改性，能够化学结合氧化钽表面并改善羟基磷灰石的形成过程。这些混合无机/有机涂层的特性和质量通过 XPS、SEM、TEM、剥离试验、接触角测量和电化学特性（自由电位、极化曲线）进行评估。
