Dipartimento di Scienze Molecolari Agroalimentari, Università degli Studi di Milano, via Celoria 2, Milan, Italy.
Chem Biol Drug Des. 2012 May;79(5):780-9. doi: 10.1111/j.1747-0285.2012.01343.x. Epub 2012 Feb 20.
The synthesis of a series of cyclooctadiene anhydrides, analogues of the natural compound zopfiellin, was performed to assay their in vitro and in vivo antifungal activity on a set of plant pathogenic fungi. Most of the synthesized compounds possessed a broad spectrum of activity. In particular, the anhydrides 2 and 5a were very effective against the Oomycete diseases such as Phytophthora infestans and Pythium ultimum, reaching a level of activity well comparable with that of commercial fungicides in use. Preliminary in vivo evaluation of their protectant activity is also reported.
合成了一系列环辛二烯酐，作为天然化合物佐菲林的类似物，以评估它们对一系列植物病原真菌的体外和体内抗真菌活性。大多数合成的化合物具有广谱的活性。特别是，酐 2 和 5a 对卵菌病害如马铃薯晚疫病菌和终极腐霉非常有效，其活性水平与目前使用的商业杀真菌剂相当。还报道了它们的保护活性的初步体内评价。
