Department of Pathology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pathol Res Pract. 2012 Mar 15;208(3):167-8. doi: 10.1016/j.prp.2011.12.006. Epub 2012 Jan 28.
The arrangement of tissue samples in a matrix, known as the tissue microarray (TMA) method, is a well-recognized method worldwide. This technique makes it possible to assess the expression of molecular markers on a large scale with high yields in terms of time, costs, and archived material. Some researchers are trying to adapt the technique to expand the research possibilities. This study proposes an adaptive simplification of low-cost instruments for obtaining samples that will be used in the construction of the TMA. The use of a manual leather puncher, which has a very low cost and a long expected life and eliminates the need to use a press machine, is a simple and effective alternative to building blocks of tissue microarrays.
组织样本在矩阵中的排列，即组织微阵列（TMA）方法，是一种在全球范围内得到广泛认可的方法。这项技术使得大规模评估分子标记物的表达成为可能，在时间、成本和存档材料方面都有很高的产出。一些研究人员正试图改进这项技术，以扩大研究的可能性。本研究提出了一种自适应简化的低成本仪器，用于获取将用于构建 TMA 的样本。使用手动皮革打孔器是一种简单而有效的替代方案，它成本非常低，预期使用寿命长，并且不需要使用压力机。
